Doripenem is a drug used to treat bacterial infections. This drug is given by a doctor by injection or by infusion into a vein.

Doripenem is a carbapenem antibiotic. This drug works by killing bacteria or stopping their growth. Doripenem cannot treat infections caused by viruses, such as the flu. Doripenem is only useful for treating infections caused by bacteria.

Doripenem trademarks:  Bizan, Daryaven, Dorbaz, Doripenem Monohydrate, Doripex, DRM, Novedor, Ribacter, Tironem

What is Doripenem

class Prescription drug
Category Carbapenems
Benefit Coping with bacterial infections
Used by Mature
Doripenem for pregnant and lactating women Category B: Animal studies have not demonstrated a risk to the fetus, but there are no controlled studies in pregnant women.

It is not known whether doripenem is absorbed into breast milk or not. Tell your doctor that you are breastfeeding if you plan to have this medication.

Drug form Powder to be used as an infusion

Warning before Using Doripenem:

Doripenem is a prescription drug that needs to be used according to doctor's instructions. Pay attention to the following points before using doripenem:

Do not use doripenem if you are allergic to it or to other carbapenem antibiotics , such as biapenem, ertapenem, imipenem-cilastin, or meropenem.
Tell your doctor if you are taking other medications, supplements, or herbal products.
Tell your doctor if you have had or are currently suffering from a central nervous system disorder, head injury, stroke, seizure , epilepsy, or kidney disease .
Tell your doctor if you are pregnant, breastfeeding or planning a pregnancy.
Tell your doctor if you are planning or have recently had a live bacterial vaccine, such as typhoid vaccine, because doripenem may decrease the effectiveness of these vaccines.
See a doctor immediately if you have an allergic drug reaction, overdose, or serious side effects.
Doripenem Dosage and Rules for Use
The following is the dosage of doripenem based on the conditions being treated:

Condition: Gastrointestinal infection with complications

Adult: 500 mg every 8 hours, given by infusion into a vein over 1 hour. Drugs are given for 5–14 days.
Condition: Complicated urinary tract infection or kidney infection (pyelonephritis)

Adult: 500 mg every 8 hours, given by infusion into a vein over 1 hour. The drug is given for 10 days. The duration of treatment can be 14 days if the patient has bacteremia .
How to Use Doripenem Properly
Doripenem is given by a doctor or medical officer on the doctor's instructions through infusion into a vein.

Do not stop treatment with doripenem before the time determined by the doctor, because there is a risk of recurrence of the infection. Consult a doctor if your condition does not improve or gets worse.

Make sure to carry out medical examinations, such as blood tests and kidney function tests, according to the schedule given by the doctor. This examination was carried out to check the effectiveness of doripenem and possible side effects.

Doripenem Interactions with Other Drugs
The use of doripenem together with certain drugs can cause interaction effects in the form of:

Increased blood levels of doripenem when taken with probenecid
Decreasing the effectiveness of valproic acid thereby increasing the risk of seizures
Decreased effectiveness of vaccines with live bacteria, such as cholera vaccine or typhoid vaccine
Doripenem Side Effects and Dangers
Side effects that may arise from the use of doripenem are:

Irritation of the area injected with the infusion needle
Stomach ache
Consult a doctor if these side effects do not improve or get worse. Immediately see a doctor if an allergic drug reaction or more serious side effects occur, such as:

Feeling very tired or weak
Colitis , which is characterized by symptoms of abdominal pain, stomach cramps, watery bowel movements, or bloody bowel movements

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